The 180 degree rule from movies also applies to comics.
Once you’ve placed characters on one side of each other, you’ve oriented the viewer. Changing that placement is awkward unless you show something has changed what’s going on.
i.e. if Cyclops is on the left side of the panel and Wolverine is on the right, then in the next panel Wolvie is on the left and Cyke is on the right with no explanation, the scene will look weird.
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